GERMINATE: GEneRating Mucosal immunity after INfluenzA infection and vaccination in lung and lymphoid TissuE
If they meet our criteria, participants may then be invited to the full screening visit.
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Vaccine arm
The vaccine arm involves a baseline visit on Day -14 (14 days before) and Day -1 (one day before) the vaccination visit.
After this, participants will be required to attend outpatient follow up visits on Day 1 (one day after), Day 3 (3 days after), Day 7 (7 days after), Day 10, Day 14, Day 28, Day 90 and Day 180.
Participants will undergo nasal biopsies OR bronchoscopies which will be explained in detail by the study team.
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Participants in the vaccine arm will be paid up to £1,205 for time and inconvenience.
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Challenge arm
The challenge arm involves a baseline visit on Day -14 (14 days before) the residential stay.
Participants will be admitted to the residential facility on Day -1 (one day before) they are to be deliberately infected with the flu virus.
Participants will then remain in the residential facility until Day 8 if they remain uninfected, or until Day 10 if they become infected with flu.
After this, participants will return for outpatient follow up visits on Day 14, Day 28, Day 90 and Day 180.
Participants will undergo nasal biopsies OR bronchoscopies which will be explained in detail by the study team.
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Participants in the challenge arm will be paid up to £2,735 for time and inconvenience.
