Are you struggling with your weight and use of alcohol?

Are you struggling with your weight and use of alcohol?

Researchers are investigating whether a known medication, combined with behavioural support, can help people reduce their alcohol use and improve their physical health.

If you're interested in taking part, please click below to fill in a brief eligibility survey.

About the study

About the study

About the study

This is a randomised, double-blind study — meaning you'll be randomly assigned to receive either the study medication or a placebo, and neither you nor the study team will know which one you're receiving.

This is a randomised, double-blind study — meaning you'll be randomly assigned to receive either the study medication or a placebo, and neither you nor the study team will know which one you're receiving.

What's involved

What's involved

What's involved

  • Screening visit: A health assessment with the study doctor to confirm you're eligible

  • 8 weekly visits: A weekly injection of either the study medication or a placebo, plus a short session of Take Control — a computer-based programme designed to help reduce alcohol use (around 20 minutes per session)

  • End-of-treatment visit (week 9): A final health check and questionnaires

  • Follow-up (week 12): A phone or in-person check-in to see how you're getting on


Between visits, you'll be asked to use a short daily phone app (SEMA) to log your mood and cravings.

All injections are administered by trained study staff.

Who can take part?

Who can take part?

Who can take part?

You may be eligible to take part if you:

Are 18 or over

  • Are above a healthy weight (overweight or obese)

  • Are drinking heavily and would like to cut down

  • Are based in Sydney and able to attend clinic visits at Royal Prince Alfred Hospital

  • Are not currently pregnant or breastfeeding

Compensation

Compensation

Compensation

You will be reimbursed for your time with gift vouchers to the equivalent of:

  • Up to $60 for completing the daily phone app questionnaire

  • $40 for each of the two follow-up visits ($80 in total)

We want to hear from you

We want to hear from you

Alcohol use and weight difficulties often go hand in hand — and there are currently very few treatment options that address both together. Your participation could help change that.

If you're interested in taking part, click below to get started.

Alcohol use and weight difficulties often go hand in hand — and there are currently very few treatment options that address both together. Your participation could help change that.

If you're interested in taking part, click below to get started.

This study has been approved by the Human Research Ethics Committee (RPAH Zone), Sydney Local Health District (ethics approval number: X25-0171). Conducted by the Edith Collins Centre, Royal Prince Alfred Hospital.

This study has been approved by the Human Research Ethics Committee (RPAH Zone), Sydney Local Health District (ethics approval number: X25-0171). Conducted by the Edith Collins Centre, Royal Prince Alfred Hospital.

This study has been approved by the Human Research Ethics Committee (RPAH Zone), Sydney Local Health District (ethics approval number: X25-0171). Conducted by the Edith Collins Centre, Royal Prince Alfred Hospital.

All rights reserved. Copyright 2026.

All rights reserved. Copyright 2026.